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polyphenol extract

Development stage: Preclinical
Modality: Small Molecules
Administration: Oral

Overview

Polyphenol extract is a natural product derived from extra-virgin olive oil (EVOO) that has demonstrated anti-inflammatory and joint protective effects. It has been investigated in experimental models of rheumatoid arthritis, where it was shown to reduce joint edema, cell migration, cartilage degradation, and bone erosion. Its mechanism of action involves the inhibition of key inflammatory signaling pathways and enzymes, leading to a reduction in proinflammatory mediators.

Other names: extra-virgin olive-oil polyphenol extract

Targets

NF-κBJNK (Mitogen-activated protein kinase kinase kinase family)PTGES (Microsomal prostaglandin E synthase-1)STAT3 (Signal Transducer and Activator of Transcription 3)RK (Ribokinase)

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