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Drug intelligence / Profile preview
polyphenol extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Polyphenol extract is a natural product derived from extra-virgin olive oil (EVOO) that has demonstrated anti-inflammatory and joint protective effects. It has been investigated in experimental models of rheumatoid arthritis, where it was shown to reduce joint edema, cell migration, cartilage degradation, and bone erosion. Its mechanism of action involves the inhibition of key inflammatory signaling pathways and enzymes, leading to a reduction in proinflammatory mediators.
- Other names
- extra-virgin olive-oil polyphenol extract
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)JNK (Mitogen-activated protein kinase kinase kinase family)NF-κBPTGES (Microsomal prostaglandin E synthase-1)RK (Ribokinase)MAPK14 (p38 mitogen-activated protein kinase alpha)
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