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Polyvac Peanut is a novel therapeutic vaccine under development for the prevention and treatment of peanut allergy. It utilizes virus-like particle (VLP) technology by coupling recombinant peanut allergen to a virus-like particle adjuvant. This design aims to induce protective immunity while minimizing the risk of triggering allergic reactions. Preclinical studies have demonstrated that a single dose can protect against systemic anaphylaxis in sensitized animal models and that the vaccine is hypoallergenic with reduced IgE binding capacity and basophil activation compared to traditional peanut extracts. The vaccine is being developed as a short-course immunotherapy intended for subcutaneous or intravenous administration, offering potential advantages in safety and patient convenience over existing oral immunotherapies[1][2][3][4][6][8].
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