polyvalent human immunoglobulin

Polyvalent human immunoglobulin is a purified form of human immunoglobulin G and other proteins derived from pooled human plasma from thousands of donors. It contains primarily IgG (with four subclasses: IgG1, IgG2, IgG3, and IgG4) and works through multiple mechanisms including Fc-dependent and F(ab')2-dependent actions. It interacts with cytokines, complement, Fc receptors, and several cell surface immunocompetent molecules, impacting different effector cells of the immune system and regulating a wide range of genes. IVIG is used for replacement therapy in immunodeficiency disorders and as an immunomodulator in various autoimmune and inflammatory conditions.

Brand names

PrivigenPanzygaAlygloHyqvia

Other names

intravenous immunoglobulinIVIGimmune globulin intravenoushuman immunoglobulin G