Drug intelligence / Profile preview

polyvalent mechanical bacterial lysate

Development stage
Phase 4
Lead developer
Lallemand Pharma
Modality
Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Sublingual
01

Overview

Polyvalent mechanical bacterial lysate is Lallemand Pharma's standardized, sublingual immunostimulant active ingredient, consisting of antigenic material from 13 strains of heat-inactivated respiratory bacterial pathogens that are mechanically disrupted by high-pressure lysis. The manufacturing approach is intended to preserve particulate bacterial antigens and promote mucosal and systemic immune responses, including immune surveillance and defense against recurrent respiratory infections. It is marketed under country-specific brands including Ismigen, Immubron, Respibron, PIR-05, and Pulmigen. ([lallemandpharma.com](https://www.lallemandpharma.com/production/polyvalent-mechanical-bacterial-lysate/))

Brand names
IsmigenImmubronRespibronPIR-05PIR05PIR 05Pulmigen
Other names
PMBLmechanical bacterial lysate
02

Targets

TLR (Toll-like receptors)

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