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polyvinyl alcohol microspheres
- Development stage
- Unknown
- Lead developer
- Boston Scientific
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Intra-arterial
01
Overview
Polyvinyl alcohol (PVA) microspheres are permanent embolic agents used in interventional oncology, specifically for transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) and other hypervascular tumors. These microspheres are engineered from polyvinyl alcohol, a biocompatible and non-absorbable polymer, to provide mechanical occlusion of the tumor's blood supply. This occlusion induces local ischemia and tumor necrosis while potentially increasing the local concentration of co-administered chemotherapeutic drugs. A specific product mentioned in clinical literature is 8spheres, developed by Jiangsu Hengrui Pharmaceutical, which features microspheres in the 100–300 μm size range. Unlike temporary agents like gelatin sponges, PVA microspheres provide a more permanent vascular blockage, though they may be associated with higher transient elevations in liver enzymes due to the completeness of the embolization.
- Brand names
- 8spheres
- Other names
- PVA microspheresblank PVA microspheres8SM
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