polyvinylpyrrolidone + sodium hyaluronate

Polyvinylpyrrolidone + sodium hyaluronate is a combination of two polymers used primarily as a topical bioadherent gel or solution for mucosal protection. Polyvinylpyrrolidone (PVP) acts as a film-forming agent, while sodium hyaluronate (the salt form of hyaluronic acid) provides lubrication and moisture retention. Together, they form a protective barrier over mucosal surfaces, such as the oral cavity or ocular surface, reducing pain and irritation from conditions like oral mucositis and dry eye syndrome. The combination has been shown to be more effective than either component alone in protecting epithelial tissue and maintaining goblet cell density in preclinical models[1][2][5][7][8]. Its primary mechanism is physical protection via mucoadhesion rather than pharmacological receptor targeting.

Brand names

Gelclair

Other names

polyvinylpyrrolidone-sodium hyaluronate gel