Drug intelligence / Profile preview

pomegranate peel aqueous extract

Development stage
Preclinical
Administration
Oral, Topical
01

Overview

Pomegranate peel aqueous extract is a botanical preparation derived from the fruit husks of *Punica granatum*. It is characterized by a high concentration of bioactive polyphenols, including hydrolyzable tannins such as punicalagin, as well as flavonoids and phenolic acids. In preclinical models, the extract has demonstrated significant antioxidant, anti-inflammatory, and immunomodulatory activities. It works by scavenging free radicals and downregulating pro-inflammatory mediators, including TNF-α, NF-κB, and iNOS. Research has explored its potential in protecting against selenite-induced cataracts, toluene-induced hepatotoxicity, and intestinal mucosal damage. Additionally, it has shown scolicidal activity against *Echinococcus granulosus*, particularly when used as an adjunct to standard anthelmintic therapy like albendazole.

Other names
Punica granatum peel aqueous extractPGEPAEpomegranate peel extract
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))NF-κBNOS2 (Nitric Oxide Synthase 2)

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