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pomiferin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Topical, Ophthalmic, Buccal, Intraperitoneal, Subcutaneous, Intramuscular, Intrathecal, Transdermal, Rectal, Vaginal, Inhalation
01
Overview
Pomiferin is a naturally occurring prenylated isoflavone isolated from Osage orange that has been investigated as an experimental **small-molecule antineoplastic agent** for overcoming cancer drug resistance. Preclinical data indicate that pomiferin inhibits sarco/endoplasmic reticulum calcium ATPase, increasing intracellular calcium and activating the CaMKKβ-AMPK-mTOR signaling axis to induce autophagic cell death in apoptosis-resistant cancer cells. The same study also reported direct inhibition of P-glycoprotein mediated drug efflux, with selective reversal of ABCB1-associated multidrug resistance and potentiation of cisplatin activity in resistant tumor models. Evidence provided is preclinical, with activity shown in mouse models of lung cancer metastasis suppression and cisplatin-resistant prostate cancer.
- Other names
- pomiferin
02
Targets
mTOR (Mammalian target of rapamycin kinase)ATP2A (Sarcoplasmic reticulum Ca2+-ATPase)HDAC (HDAC family)ABCB1 (P-glycoprotein)
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