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ponatinib + cytarabine
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Ponatinib + cytarabine is a combination therapy used primarily in hematological malignancies. Ponatinib is a multi-target tyrosine kinase inhibitor that targets BCR-ABL including the T315I mutation, as well as VEGFR, PDGFR, FGFR, EPH receptors, KIT, RET, TIE2, and FLT3. Cytarabine is a cytotoxic antimetabolite that inhibits DNA synthesis. This combination has been studied in blast-phase chronic myeloid leukemia, FLT3-mutated acute myeloid leukemia, and Philadelphia chromosome-positive acute lymphoblastic leukemia.
02
Targets
BCR-ABL1 T315I (Bcr-Abl T315I mutant protein)FGFR (Fibroblast growth factor receptor)KIT (c-KIT proto-oncogene receptor tyrosine kinase)DNA polymerase familyVEGFR (VEGFR family)ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)TEK (Tie2)PDGFR (PDGFR family)RET (Rearranged during transfection receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)
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