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Drug intelligence / Profile preview
Ponostop
- Development stage
- Unknown
- Lead developer
- AFANDI
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
**Ponostop** is a topical fixed-dose analgesic and anti-inflammatory ointment marketed by NI-THE for joint and muscular pain and inflammation. It combines diethylamine salicylate, a topical salicylate analgesic with anti-inflammatory activity; capsaicin, which activates and subsequently desensitizes TRPV1-expressing nociceptive sensory neurons; and camphor, a topical counterirritant that produces a cooling sensation. The product is supplied as a 40 g ointment tube for topical cutaneous use.
- Brand names
- Ponostop
- Other names
- camphor + capsaicin + diethylamine salicylate
02
Targets
TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPV3 (Transient receptor potential vanilloid subtype 3)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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