Drug intelligence / Profile preview

Populus fremontii pollen

Development stage
Unknown
Lead developer
Greer Laboratories
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Intradermal, Percutaneous, Subcutaneous, Sublingual
01

Overview

Populus fremontii pollen is a non-standardized allergenic extract derived from the pollen of the Fremont Cottonwood tree (Populus fremontii). It is classified as a biologic and is used for both the diagnosis and treatment of immediate hypersensitivity allergic reactions. For diagnosis, the extract is administered via percutaneous or intradermal skin tests to elicit a localized IgE-mediated response in sensitized individuals. For treatment, it is used in allergen immunotherapy (allergy shots), administered subcutaneously in gradually increasing doses. This process aims to induce immune tolerance, shifting the body's response from a pro-allergic Th2 profile to a more tolerant Th1/Treg profile, thereby reducing or eliminating allergic symptoms upon natural exposure to the pollen. The product is developed and manufactured by companies such as Greer Laboratories and Allermed Laboratories and is available in multi-dose vials, sometimes as a component of regional tree pollen mixes.

Other names
Fremont Cottonwood pollenFremont's Cottonwood pollenFremont Cottonwood pollen extractArizona Cottonwood pollen
02

Targets

MHC II (Major histocompatibility complex class II receptor)IgE (Immunoglobulin E)

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