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porcine-derived small intestinal submucosa
- Development stage
- Unknown
- Lead developer
- Cook Biotech
- Administration
- Topical, Surgical Implantation
01
Overview
Porcine-derived small intestinal submucosa (SIS) is a biologic extracellular matrix (ECM) scaffold derived from the submucosal layer of the porcine jejunum. It is a decellularized, non-crosslinked material composed primarily of type I collagen, along with elastin, glycosaminoglycans, proteoglycans, and fibronectin. SIS also retains endogenous growth factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and transforming growth factor-beta (TGF-β). Once implanted, SIS acts as a temporary scaffold that promotes host tissue remodeling by facilitating cell recruitment, proliferation, and site-specific differentiation, eventually being replaced by native tissue. It is widely used in wound care (chronic ulcers), hernia repair, urogenital reconstruction, and cardiovascular applications.
- Brand names
- OasisCorMatrixBiodesignSurgiSIS
- Other names
- porcine small intestinal submucosasmall intestinal submucosaporcine SISSIS-ECM
02
Targets
TGFB1 (Transforming growth factor Beta-1 proprotein)NeuraminidaseFGF2VEGFA (Vascular endothelial growth factor A)
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