poricoic acid a

Poricoic acid A is a **tetracyclic triterpenoid** compound isolated from the surface (epidermis) of the medicinal fungus *Poria cocos* (Fuling). It exhibits **antitumor activity** by inhibiting cancer cell growth (notably in lung cancer models) through suppression of the MEK/ERK signaling pathway[1]. In preclinical settings, poricoic acid A also demonstrates strong **anti-fibrotic effects**, notably in kidney disease models, by inhibiting TGF-β1-induced renal fibroblast activation, extracellular matrix (ECM) accumulation, and fibrosis formation through downregulation of the **PDGF-C/Smad3/MAPK pathways** as well as by upregulating Sirt3 and modulating β-catenin acetylation[3][5][7]. It has shown **low toxicity** in animal studies and is actively researched for its roles in chronic kidney disease and fibrosis as well as cancer[1][3][7].

Other names

poricoic acid a(f)poricoic acid a, 10 mM in DMSO(2R,3R,3aR,6S,7S,9bR)-3-[(1R)-1-Carboxy-5-methyl-4-methylenehexyl]-2,3,3a,4,6,7,8,9b-octahydro-2-hydroxy-3a,6,9b-trimethyl-7-(1-methylethenyl)-1H-benz[e]indene-6-propanoic acid1H-Benz[e]indene-6-propanoic acid, 3-[(1R)-1-carboxy-5-methyl-4-methylenehexyl]-2,3,3a,4,6,7,8,9b-octahydro-2-hydroxy-3a,6,9b-trimethyl-7-(1-methylethenyl)-, (2R,3R,3aR,6S,7S,9bR)-(R)-2-((2R,3R,3aR,6S,7S,9bR)-6-(2-Carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,6,7,8,9b-octahydro-1H-cyclopenta[a]naphthalen-3-yl)-6-methyl-5-methyleneheptanoic acid