posaconazole

Posaconazole is a triazole antifungal drug used to treat and prevent serious invasive fungal infections, particularly in immunocompromised patients. It is effective against Candida, Aspergillus, and Mucorales species. The drug works by inhibiting the fungal enzyme lanosterol 14α-demethylase (a cytochrome P450 enzyme), which blocks ergosterol synthesis—a critical component of the fungal cell membrane—leading to impaired cell membrane function and ultimately fungal cell death. It is structurally related to itraconazole but has enhanced potency and spectrum due to specific chemical modifications[4][6][7]. Approved indications include prophylaxis of invasive Aspergillus and Candida infections in high-risk patients (such as those with hematologic malignancies or undergoing stem cell transplantation), treatment of oropharyngeal candidiasis (including cases refractory to other azoles), and treatment of invasive aspergillosis[2][3][4][7].

Brand names

NoxafilPosaconazole AHCLPosaconazole AccordPosanol

Other names

泊沙康唑