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positron emission tomography-Centre Hospitalier Universitaire de Saint Etienne-bulimia nervosa
- Development stage
- Unknown
- Lead developer
- Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)
- Modality
- Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules, Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
01
Overview
This designation refers to a clinical research study conducted by the Centre Hospitalier Universitaire de Saint Etienne (CHU de Saint Etienne) to evaluate the efficacy of serotonergic antidepressants in patients with bulimia nervosa. The study utilizes [18F]MPPF, a radiopharmaceutical that acts as a selective 5-HT1A receptor antagonist, for positron emission tomography (PET) imaging to determine brain serotonin profiles. These profiles are then correlated with the clinical response to fluoxetine, a selective serotonin reuptake inhibitor (SSRI) small molecule drug that targets the serotonin transporter (SERT). Fluoxetine is the primary therapeutic agent used in the study, typically administered at high doses to manage bulimic symptoms, while [18F]MPPF serves as a diagnostic tool to visualize serotonergic abnormalities.
- Brand names
- Prozac
- Other names
- Evaluation of the Efficacy of Serotoninergic Antidepressants in Bulimia Nervosa, According to Brain Serotonin Profile Determined by Positron Emission Tomography With [18F] MPPFPET Imaging and SSRI Efficacy in Bulimia Nervosafluoxetine
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))SERT (Sodium-dependent serotonin transporter)
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