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potassium chloride + calcium chloride + magnesium chloride + sodium chloride
- Development stage
- Unknown
- Lead developer
- Baxter Healthcare Corporation
- Modality
- Small Molecules
- Administration
- Intracardiac
01
Overview
Potassium chloride + calcium chloride + magnesium chloride + sodium chloride is a **sterile cardioplegic electrolyte solution** used during open heart surgery to induce rapid, reversible cardiac arrest when administered after buffering, typically in conjunction with ischemia and hypothermia. The pharmacologic effect is driven primarily by the high-potassium electrolyte environment, which depolarizes cardiac myocytes and stops electromechanical activity, while sodium, calcium, and magnesium help maintain ionic composition and myocardial preservation during cardioplegia. This product is marketed as **Plegisol** and has also been manufactured as a comparable cardioplegic solution by **Baxter**; it is supplied as an injection solution intended to be buffered with sodium bicarbonate before cardiac instillation.
- Brand names
- Plegisol
- Other names
- potassium chloride + calcium chloride + magnesium chloride + sodium chloridecardioplegic solutionpotassium chloride + sodium chloride + calcium chloride + magnesium chloride
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