potassium-enriched salt substitute

Potassium-enriched salt substitute is a dietary intervention designed to reduce sodium intake and increase potassium intake by replacing a portion of sodium chloride (NaCl) with potassium chloride (KCl). The most commonly studied formulation, utilized in the landmark Salt Substitute and Stroke Study (SSaSS), consists of 75% NaCl and 25% KCl. This substitute is primarily used to lower blood pressure and reduce the risk of major adverse cardiovascular events (MACE), including stroke and myocardial infarction. Clinical evidence from large-scale trials has demonstrated that its use significantly reduces all-cause mortality and cardiovascular events compared to regular table salt. Recent post hoc analyses have also indicated that the substitute does not significantly increase the risk of clinical hyperkalemia, even in patients concurrently using renin-angiotensin-aldosterone system (RAAS) blockers, although it is generally contraindicated in individuals with severe chronic kidney disease.

Other names

potassium-enriched saltlow-sodium salt substituteSSaSS salt