Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
potassium hydroxypentylbenzoate
- Development stage
- Unknown
- Lead developer
- Yunnan Biovalley
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Potassium hydroxypentylbenzoate (PHPB) is a water-soluble potassium salt of the ring-opened form of 3-n-butylphthalide (NBP), a neuroprotective compound originally derived from celery seeds (*Apium graveolens*). Developed by Yunnan Biovalley Innovative Pharmaceutical, PHPB was designed to improve the solubility and pharmacokinetic profile of NBP, facilitating its use as an intravenous injection for acute ischemic stroke. The drug exerts neuroprotective effects through multiple pathways, including the improvement of cerebral microcirculation, stabilization of mitochondrial function, reduction of oxidative stress via the Nrf2 pathway, and inhibition of neuronal apoptosis by suppressing caspase-3 activity. It is currently in late-stage clinical development in China for the treatment of acute ischemic stroke and cerebral infarction.
- Other names
- potassium 2-(1-hydroxypentyl)benzoatepotassium hydroxypentylbenzoate
02
Targets
NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)CASP3 (Caspase-3)
Beyond the preview
Go deeper on potassium hydroxypentylbenzoate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on potassium hydroxypentylbenzoate.