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Potassium magnesium citrate is an orally administered mixed potassium-magnesium citrate salt used as a pharmaceutical powder formulation dissolved in water in University of Texas Southwestern Medical Center clinical studies. It supplies potassium, magnesium, and citrate-derived alkali, with the investigational rationale of reproducing selected mineral and alkali components of the DASH diet to lower blood pressure and improve arterial stiffness. It has also been studied during chlorthalidone treatment to reduce thiazide-associated potassium and magnesium depletion and attenuate increases in fasting plasma glucose. ([cdn.clinicaltrials.gov](https://cdn.clinicaltrials.gov/large-docs/09/NCT05145309/Prot_SAP_000.pdf))
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