potassium phosphate + sodium phosphate

Potassium phosphate + sodium phosphate (commonly referred to as neutral phosphate) is an oral phosphorus supplement and urinary modifier. It is a fixed-dose combination of monobasic and dibasic sodium and potassium phosphate salts formulated to maintain a neutral pH of approximately 7.0. The drug is primarily indicated for the treatment and prevention of hypophosphatemia and to prevent the recurrence of calcium-containing kidney stones (such as calcium oxalate and calcium phosphate stones). By increasing serum phosphate levels, it downregulates the synthesis of active vitamin D (1,25-dihydroxyvitamin D), which subsequently decreases intestinal calcium absorption and urinary calcium excretion. Additionally, it increases the urinary excretion of pyrophosphate, a potent natural inhibitor of calcium stone crystallization. The University of Chicago has conducted clinical trials evaluating low-dose neutral phosphate supplementation specifically for patients with recurrent calcium oxalate kidney stones and hypophosphatemia.

Brand names

K-Phos NeutralNeutra-PhosPhos-NaKPhospha 250 NeutralPhospha250 NeutralPhospha-250 NeutralPhospho-Trin 250 NeutralPhospho-Trin250 NeutralPhospho-Trin-250 NeutralUro-KP-NeutralVirt-Phos 250 NeutralVirt-Phos250 NeutralVirt-Phos-250 NeutralWes-Phos 250 NeutralWes-Phos250 NeutralWes-Phos-250 Neutral

Other names

neutral orthophosphateneutral phosphateorthophosphatepotassium acid phosphate and sodium acid phosphatepotassium phosphate and sodium acid phosphatepotassium phosphate and sodium phosphatesodium potassium phosphate