Ppc-1

Ppc-1 is a natural prenylated quinolinecarboxylic acid (PQA) derivative originally isolated from the fruiting bodies of the cellular slime mold *Polysphondylium pseudo-candidum*. It exhibits a dual pharmacological profile characterized by antibacterial activity against periodontopathogens like *Porphyromonas gingivalis* and anti-inflammatory effects mediated through the inhibition of the NF-κB signaling pathway and the suppression of pro-inflammatory cytokines such as Interleukin-2 (IL-2). Research indicates its potential as a lead compound for treating periodontal diseases and as a scaffold for developing novel immunosuppressants. Ppc-1 served as the structural lead for the development of synthetic derivatives like PQA-18, which acts as a potent inhibitor of p21-activated kinase 2 (PAK2).

Other names

3-methylbut-2-enyl 4-methoxy-8-[(3-methylbut-2-enyl)oxy]quinoline-2-carboxylateprenylated quinolinecarboxylic acid derivative