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pPJV2012
- Development stage
- Discontinued
- Lead developer
- Pfizer
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Transdermal
01
Overview
pPJV2012 is a DNA-encoded immunostimulator consisting of a plasmid that expresses human Interleukin-12 (IL-12). Developed by PowderJect Pharmaceuticals (later acquired by Chiron and subsequently Novartis), it was designed as a genetic adjuvant to enhance the cellular immune response to DNA vaccines. The plasmid is typically administered via Particle Mediated Epidermal Delivery (PMED), a "gene gun" technology that delivers DNA-coated gold microparticles directly into the epidermis. In clinical development, pPJV2012 was evaluated in combination with pPJV7630, a therapeutic DNA vaccine targeting Herpes Simplex Virus type 2 (HSV-2), to boost Th1-biased T-cell responses in latently infected individuals. Following the acquisition of Chiron by Novartis, the program was discontinued.
- Other names
- DNA-encoded IL-12IL-12 DNA plasmidIL12 DNA plasmidIL 12 DNA plasmidpPJV2012 plasmidpPJV-2012 plasmidpPJV 2012 plasmid
02
Targets
IL12 (Interleukin-12)
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