Drug intelligence / Profile preview

PPP005

Development stage
Discontinued
Lead developer
Tetra Bio-Pharma
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**PPP005** is an investigational oral encapsulated cannabis-oil product developed by Tetra Bio-Pharma. It contains a fixed 1:1 combination of cannabidiol and delta-9-tetrahydrocannabinol; the reported capsule formulation contains 10 mg of each cannabinoid. PPP005 was evaluated for chronic pain and for cancer pain as an adjunct to palliative radiotherapy. Its analgesic pharmacology is primarily attributed to delta-9-tetrahydrocannabinol activity at cannabinoid receptors, while cannabidiol contributes broader, pleiotropic cannabinoid-system pharmacology. The registered chronic-pain and cancer-pain studies were terminated. ([marijuanastocks.com](https://marijuanastocks.com/tetra-bio-pharma-tbpmf-clinical-study-on-cannabis-oil-capsules-for-patients-suffering-from-chronic-pain-should-be-completed-by-fall-2018/))

02

Targets

CNR1 (Cannabinoid receptor 1)

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