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PPV-06
- Development stage
- Phase 2
- Lead developer
- Peptinov
- Modality
- Peptide-based Cancer Vaccines → Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
PPV-06 is a peptide-based active immunotherapy (vaccine) designed to induce the production of anti-interleukin 6 (IL-6) antibodies, thereby neutralizing IL-6 and reducing its pro-inflammatory activity. The drug consists of an IL-6-derived peptide conjugated to the carrier protein CRM197. Its primary mechanism is to stimulate the immune system to generate neutralizing antibodies against IL-6, a cytokine implicated in pain and disease progression in osteoarthritis and other inflammatory conditions. Developed by Peptinov, PPV-06 has demonstrated safety and immunogenicity in phase 1 clinical trials for knee osteoarthritis, with ongoing development for this indication[1][2][3][4][5][7][8].
- Other names
- Anti-IL-6 vaccine - PeptinovAnti-IL6 vaccine - PeptinovAnti-IL 6 vaccine - Peptinov
02
Targets
IL-6 (Interleukin 6)
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