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PPZ2

Development stage: Unknown
Modality: Small Molecules
Administration: In Vitro Research Use Only (not Approved For Human Or Veterinary Use)

Overview

PPZ2 is a synthetic small molecule that functions as a **selective activator of TRPC3, TRPC6, and TRPC7 channels**. These are members of the **transient receptor potential canonical (TRPC) family** of calcium-permeable cation channels. PPZ2 is diacylglycerol (DAG)-activated and is used primarily in research to promote **neuronal development and survival** by facilitating calcium influx through TRPC channels. PPZ2 has also been used as a tool molecule in cell biology to study **Ca2+ signaling** and TRPC channel physiology[1][2][6].

Other names: 2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide

Targets

TRPC7TRPC3

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