PQ1

PQ1 is a small molecule substituted quinoline derivative that functions as a gap junction enhancer. It works by increasing gap junctional intercellular communication (GJIC) through the upregulation of gap junction proteins, specifically Connexin 43 (Cx43) and Connexin 26 (Cx26). In oncology research, PQ1 is utilized to sensitize tumor cells to chemotherapy by facilitating the "bystander effect," where cytotoxic drugs or their metabolites are transferred between adjacent cells via gap junctions. Preclinical studies, particularly in breast cancer models, have demonstrated that PQ1 significantly enhances the efficacy of antineoplastic agents like cisplatin by increasing apoptosis and reducing tumor growth.

Other names

6,7-dimethoxy-2-phenylquinolinePQ-1PQ1PQ 1