PQ7

PQ7 is a small molecule substituted quinoline that acts as a gap junction enhancer. Developed by researchers at Kansas State University, it is designed to increase gap junctional intercellular communication (GJIC) in cancer cells by promoting the expression and functional activity of gap junction proteins, specifically **Connexin 43 (Cx43)** and **Connexin 26 (Cx26)**. By enhancing GJIC, PQ7 facilitates the "bystander effect," allowing for the more efficient transfer of cytotoxic agents or apoptotic signals between adjacent tumor cells. In preclinical mammary tumor models, PQ7 has demonstrated the ability to significantly potentiate the efficacy of antineoplastic drugs such as cisplatin, leading to enhanced tumor growth inhibition compared to chemotherapy alone.

Other names

PQ-7PQ7PQ 7substituted quinoline PQ7