Drug intelligence / Profile preview

prabotulinumtoxinA

Development stage: Approved
Lead developer: Daewoong Pharmaceutical
Modality: Recombinant Proteins and Enzymes, Bacterial Toxin Conjugates → Immunotoxins → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intramuscular

Overview

PrabotulinumtoxinA is a 900 kDa botulinum toxin type A produced from fermentation of Clostridium botulinum. It blocks neuromuscular transmission by binding to acceptor sites on motor nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This mechanism temporarily reduces muscle activity in the targeted area. It is primarily used for the temporary improvement in the appearance of moderate to severe glabellar lines (frown lines between the eyebrows) associated with corrugator and/or procerus muscle activity in adult patients.

Brand names: JeuveauNabotaNuceivaEvosyal
Other names: prabotulinumtoxinA-xvfs

Targets

GD3 (Ganglioside GD3)SV2A (Synaptic vesicle glycoprotein 2A)SNAP25 (Synaptosome-associated protein 25)

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