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pralidoxime iodide
- Development stage
- Approved
- Lead developer
- Walker's Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intramuscular, Intravenous, Subcutaneous
01
Overview
Twapam (pralidoxime iodide) is an approved injectable cholinesterase reactivator developed and manufactured by Walker's Pharmaceuticals. It is used as an antidote to treat severe poisoning caused by organophosphate pesticides, chemicals, or nerve agents, as well as to manage anticholinesterase drug overdoses (such as those used in the treatment of myasthenia gravis). Pralidoxime iodide works by binding to and reactivating the acetylcholinesterase enzyme that has been inactivated by phosphorylation, thereby restoring normal neuromuscular transmission and relieving muscle paralysis, particularly in the respiratory muscles.
- Brand names
- AldopamCanpamEryx-PamFlopamJPamMitspamPleximePro-PamTwapamTwapam Inj.
- Other names
- 2-PAM iodide2-pyridinealdoxime methiodidepralidoximepralidoxime methiodidepralidoxime monoiodidepralidoximi iodidumprotopam iodide
02
Targets
Acetylcholinesterase
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