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PRAME (A*02) T Cell Engager
- Development stage
- Preclinical
- Lead developer
- MyriO Tx
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
PRAME (A*02) T Cell Engager is a bispecific antibody in development by Myrio Therapeutics for the treatment of PRAME-positive solid tumors, including ovarian cancer and melanoma. The therapeutic is designed to recognize the PRAME (Preferentially Expressed Antigen in Melanoma) peptide presented by the HLA-A*02 major histocompatibility complex on the surface of malignant cells. By simultaneously binding to the CD3 component of the T-cell receptor complex, the drug facilitates the recruitment and activation of cytotoxic T cells, leading to the targeted destruction of tumor cells. It is currently in the discovery stage of development.
- Other names
- PRAME A*02 T-cell engager
02
Targets
CD3 (T-cell surface glycoprotein CD3)HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)PRAME (Preferentially expressed antigen in melanoma)
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