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PRAME CAR-T
- Development stage
- Preclinical
- Lead developer
- MyriO Tx
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
PRAME CAR-T is an investigational chimeric antigen receptor (CAR) T-cell therapy being developed by MyriO Tx (also known as Myrio Therapeutics). The therapy is designed to target the Preferentially Expressed Antigen in Melanoma (PRAME), a cancer-testis antigen that is highly expressed in various pediatric and adult malignancies, including neuroblastoma, while maintaining restricted expression in normal tissues. By engineering T cells to express a CAR specific for PRAME, the treatment aims to selectively identify and eliminate PRAME-positive tumor cells. It is currently in the discovery phase for the treatment of neuroblastoma and other pediatric cancers.
- Other names
- PRAME CAR TPRAME-CAR-T-cell therapy
02
Targets
Preferentially expressed antigen in melanoma (PRAME) ALYVDSLFFL peptide-HLA-A*02 complex
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