Drug intelligence / Profile preview

prazosin

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules
01

Overview

Prazosin is a small molecule drug primarily used to treat high blood pressure (hypertension), symptoms of benign prostatic hyperplasia (enlarged prostate), and nightmares associated with post-traumatic stress disorder (PTSD). It acts as an α1-adrenergic receptor antagonist, leading to vasodilation and reduced peripheral vascular resistance, which lowers blood pressure. It also relaxes smooth muscle in the prostate and bladder neck, improving urine flow. The mechanism for its effect on PTSD-related nightmares is not fully understood. Common side effects include dizziness, drowsiness, nausea, and palpitations; serious side effects may include orthostatic hypotension and depression[1][2][3].

Brand names
Minipress
Other names
哌唑嗪Prazosina
02

Targets

ADRA1A (α1A)ADRA1B (α1B)ADRA1D (α1D)

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