PRE-084

PRE-084 is a **synthetic small molecule** that acts as a **highly selective agonist at the sigma-1 receptor (σ1 receptor)**, with minimal activity on other receptors, including sigma-2, PCP, and a broad array of other unrelated targets[1][2][3][4][5][6][8][9]. It was derived from phencyclidine and is often used as a research tool to study sigma-1 receptor function and pathophysiology[1]. In animal models, PRE-084 demonstrates nootropic, neuroprotective, antidepressant, antitussive, and neurorestorative properties[1][5][7]. PRE-084 has shown promising effects in preclinical models of neurodegenerative diseases like Huntington's, ALS, and Parkinson's disease, as well as in neuroprotection and in ameliorating cognitive deficits[1][5][6][7]. No clinical trials have been reported to date[3].

Other names

1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester2-morpholinoethyl 1-phenylcyclohexanecarboxylate