pre-miR-125a-5p mimic

pre-miR-125a-5p mimic is a synthetic, double-stranded RNA molecule designed to replicate the biological activity of the endogenous tumor suppressor microRNA, miR-125a-5p. In various malignancies, including cervical carcinoma, miR-125a-5p expression is frequently downregulated, which facilitates tumor progression. By introducing this mimic, researchers can restore miR-125a-5p levels, which subsequently binds to the 3' untranslated regions (UTRs) of specific target mRNAs such as MARK1 (Microtubule Affinity Regulating Kinase 1) and VEGF (Vascular Endothelial Growth Factor). This binding leads to mRNA degradation or translational repression, effectively downregulating these proteins and resulting in cell-cycle arrest, inhibition of proliferation, and the induction of apoptosis. It is primarily utilized as a research tool to investigate miRNA-mediated gene regulation and potential therapeutic strategies in oncology.

Brand names

Pre-miR

Other names

miR-125a-5p mimicmiR125a-5p mimicmiR 125a-5p mimichsa-miR-125a-5p mimichsa-miR125a-5p mimichsa-miR 125a-5p mimic