pre-miR-148a

pre-miR-148a is a precursor microRNA molecule that serves as a template for the production of mature miR-148a. In glioblastoma research, it has been characterized as an oncogenic factor that enhances cell proliferation, migration, and invasion. Its mechanism involves the direct targeting and inhibition of MIG6 (ERRFI1), a negative regulator of the EGFR pathway, and BIM (BCL2L11), a pro-apoptotic protein. By suppressing these targets, pre-miR-148a facilitates constitutive EGFR activation and evades apoptosis, contributing to the malignancy of glioblastoma stem cells. It is primarily utilized as a research tool to investigate miRNA-mediated gene regulation and as a potential target for therapeutic intervention.

Other names

microRNA-148a precursormicroRNA148a precursormicroRNA 148a precursorhsa-mir-148ahsa-mir148ahsa-mir 148a