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Precision Cell Immunotherapy is an autologous cell-based therapeutic regimen developed by Ningbo Cancer Hospital for the treatment of advanced lung cancer. The therapy utilizes a dual-component approach consisting of autologous dendritic cells (DC) and Precision Natural Autologous T cells (PNAT). Dendritic cells are administered subcutaneously to act as professional antigen-presenting cells, stimulating the patient's immune system to recognize and respond to tumor-specific antigens. The PNAT component, which likely consists of expanded autologous effector T cells or natural killer cells, is administered intravenously to provide direct cytotoxic activity against cancer cells. In clinical trials, this immunotherapy is typically evaluated in combination with standard-of-care chemotherapy, such as cisplatin and gemcitabine, to leverage potential synergistic effects between immune activation and direct cytotoxic drug action.
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