Drug intelligence / Profile preview

Pred-Gati-Brom

Development stage
Phase 4
Lead developer
ImprimisRx
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

**Pred-Gati-Brom** is a compounded ophthalmic fixed-dose suspension containing prednisolone acetate 1%, gatifloxacin 0.5%, and bromfenac 0.075%. It is supplied by ImprimisRx for topical ocular use, including prophylaxis and management of postoperative ocular inflammation and infection following cataract surgery. Prednisolone acetate activates the glucocorticoid receptor to suppress inflammatory signaling; gatifloxacin inhibits bacterial DNA gyrase and topoisomerase IV; and bromfenac inhibits cyclooxygenase enzymes to reduce prostaglandin-mediated inflammation. Pred-Gati-Brom is a prescription compounded medication and is not an FDA-approved drug product. ([imprimisrx.com](https://www.imprimisrx.com/assets/Ophth_Catalog_D.pdf))

Brand names
Pred-Gati-Brom
Other names
prednisolone acetate + gatifloxacin + bromfenacPrednisolone Acetate-Gatifloxacin-Bromfenac
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)GR (Glucocorticoid receptor)Topo IV (Bacterial Topoisomerase IV)DNA gyrase

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