prednicarbate

Prednicarbate is a medium-potency, nonhalogenated topical corticosteroid used to treat inflammatory and pruritic manifestations of corticosteroid-responsive skin conditions such as atopic dermatitis. It is a double-ester derivative of prednisolone designed to provide strong anti-inflammatory effects with a lower risk of causing skin atrophy compared to other corticosteroids. Prednicarbate works primarily by suppressing the production and activity of pro-inflammatory cytokines like interleukin 1-alpha (IL-1α) in keratinocytes and fibroblasts, thereby reducing inflammation, redness, itching, and swelling. Its mechanism involves agonism at the glucocorticoid receptor leading to induction of phospholipase A2 inhibitory proteins (lipocortins), which block the release of arachidonic acid—a precursor for inflammatory mediators such as prostaglandins and leukotrienes[3][6][8]. Prednicarbate is considered suitable for children, elderly patients, or those requiring long-term intermittent treatment due to its favorable safety profile.

Brand names

DermatopDermatop E

Other names

PrednicarbatoPrednicarbatum