Drug intelligence / Profile preview

prednisolone-21-phosphate

Development stage
Approved
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intramuscular, Ophthalmic, Intraarticular, Soft Tissue Injection
01

Overview

Prednisolone 21-phosphate is a synthetic glucocorticoid corticosteroid ester used primarily for its anti-inflammatory and immunosuppressive effects. It acts by binding to the glucocorticoid receptor, inhibiting pro-inflammatory signals and promoting anti-inflammatory pathways. This drug is indicated for a wide range of conditions including allergic states, dermatologic diseases, edematous states (such as nephrotic syndrome), endocrine disorders (including adrenocortical insufficiency), gastrointestinal diseases, hematologic disorders, neoplastic diseases (as palliative therapy), nervous system conditions (such as multiple sclerosis exacerbations), ophthalmic diseases (inflammatory eye conditions), respiratory diseases (like asthma), and rheumatic disorders. Prednisolone phosphate is often preferred in situations where rapid onset or parenteral administration is needed due to its water solubility[1][2][3][4].

Brand names
OrapredPediapred
Other names
prednisolone phosphateprednisolone 21-(dihydrogen phosphate)prednisolone 21-monophosphateprednisolone21-monophosphateprednisolone-21-monophosphatePrednisolone Phosphoric Acid11,17-dihydroxy-21-(phosphonooxy)-Pregna-1,4-diene-3,20-dione
02

Targets

GR (Glucocorticoid receptor)

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