Drug intelligence / Profile preview

prednisone + olverembatinib + blinatumomab + chidamide

Development stage
Preclinical
Lead developer
Ascentage Pharma
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous
01

Overview

A combination therapy consisting of prednisone (a corticosteroid), olverembatinib (a third-generation BCR-ABL tyrosine kinase inhibitor), blinatumomab (a bispecific T-cell engager antibody), and chidamide (a histone deacetylase inhibitor). This regimen likely combines multiple mechanisms of action to target hematological malignancies, particularly leukemias that may be resistant to standard therapies.

02

Targets

CD19 (B lymphocyte antigen CD19)CD3 (T-cell surface glycoprotein CD3)GR (Glucocorticoid receptor)PDGFRA (Platelet-derived growth factor receptor alpha)KIT (c-KIT proto-oncogene receptor tyrosine kinase)HDAC10 (Histone Deacetylase 10)HDAC1 (Histone Deacetylase 1)ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)FGFR2 (Keratinocyte growth factor receptor)SFK (SRC family kinases)MR (Mineralocorticoid receptor)FLT3 (Fms related receptor tyrosine kinase 3)

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