Drug intelligence / Profile preview

prednisone acetate

Development stage
Approved
Lead developer
Allergan
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Ophthalmic
01

Overview

Prednisone acetate is a synthetic glucocorticoid corticosteroid and a derivative of prednisone. Glucocorticoids are anti-inflammatory and immunosuppressive agents that act by inhibiting phospholipase A2, thereby reducing the synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes. Prednisone itself is a prodrug, converted in the liver to its active form prednisolone, which then binds to glucocorticoid receptors to modulate gene expression and suppress immune responses[5]. Prednisone (and its derivatives) are used for a wide range of inflammatory and autoimmune conditions including arthritis, allergic reactions, asthma, lupus, skin diseases, certain cancers, and more[2][4][7]. However, there is little evidence or documentation supporting "prednisone acetate" as an approved or commonly used pharmaceutical product; most clinical use involves either prednisone (oral) or prednisolone/prednisolone acetate (ophthalmic)[1][6].

Brand names
醋酸泼尼松片
Other names
prednisone 21-acetateprednisone21-acetateprednisone-21-acetate17,21-dihydroxypregna-1,4-diene-3,11,20-trione 21-acetate
02

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)PLA2 (Phospholipase A2 group IID)

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