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Preemptive Brachial Plexus Blockade (University of Sao Paulo)

Development stage
Unknown
Lead developer
University of Sao Paulo General Hospital
Modality
Small Molecules
Administration
Perineural
01

Overview

This refers to a specific clinical intervention protocol developed by the University of Sao Paulo General Hospital. The protocol involves an ultrasound-guided brachial plexus blockade administered 48 hours prior to arthroscopic rotator cuff repair, followed by a standard blockade on the day of surgery. The goal of this preemptive approach is to reduce the sensitization of the peripheral and central nociceptive pathways, thereby mitigating the intense postoperative pain often experienced after the effects of a standard single-day blockade wear off. This strategy aims to improve long-term analgesic outcomes and reduce the need for potent postoperative opioids by blocking nociceptive transmission before the surgical stimulus occurs.

Other names
Preemptive groupPreemptive Brachial Plexus Blockade
02

Targets

TRPV1 (Transient receptor potential cation channel subfamily V member 1)NaV (Voltage-gated sodium channels)KATP channel (ATP-sensitive potassium channel)NMDAR (Glutamate receptor ionotropic, NMDA)TRPA1 (Transient receptor potential cation channel subfamily A member 1)

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