Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
pregabalin + imipramine
- Development stage
- Phase 4
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
The combination of pregabalin and imipramine is used for treating painful polyneuropathy. This combination therapy uses moderate doses of both medications to provide better pain relief than monotherapy with either drug alone. Pregabalin is an anticonvulsant that binds to the α2δ subunit of voltage-dependent calcium channels, while imipramine is a tricyclic antidepressant that inhibits serotonin and norepinephrine reuptake. Clinical trials have shown that the combination provides significantly better pain reduction compared to either medication used alone, though it may cause more side effects including dizziness, drowsiness, confusion, and difficulty concentrating.
- Other names
- imipramine and pregabalin combination
02
Targets
CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)CACNA2D2 (α2δ-2)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)α2δ (Voltage-gated calcium channel alpha-2-delta subunit)
Beyond the preview
Go deeper on pregabalin + imipramine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on pregabalin + imipramine.