pregnenolone

Pregnenolone is a naturally occurring endogenous neurosteroid synthesized from cholesterol in the adrenal glands and central nervous system. It serves as a precursor to various hormones, including glucocorticoids, mineralocorticoids, progestogens, androgens, estrogens, and other neuroactive steroids. It is available as an over-the-counter supplement and is being investigated for its potential therapeutic effects, including antidepressant, cognitive-enhancing, and neuroprotective properties. Its mechanism of action involves the positive modulation of NMDA receptors by its sulfated derivative and the enhancement of GABA(A) receptor signaling by its metabolite, allopregnanolone.