Preparation H (Haleon)

Preparation H is a widely recognized brand of over-the-counter medications used for the symptomatic relief of hemorrhoids. The cream formulation, which served as the active control in clinical trials conducted by Peritech Pharma Ltd., typically contains a combination of active pharmaceutical ingredients designed to address multiple symptoms. Its primary components usually include phenylephrine hydrochloride, a vasoconstrictor that reduces the swelling of hemorrhoidal tissues, and pramoxine hydrochloride, a local anesthetic that provides temporary relief from pain, itching, and discomfort. Some formulations also incorporate skin protectants such as glycerin or petrolatum to provide a physical barrier and soothe irritated mucous membranes. In the context of Peritech's development of PP110, Preparation H Cream was used as the standard-of-care comparator for treating grade 2-3 bleeding hemorrhoids.

Brand names

Preparation H

Other names

Preparation H Cream