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Previfenon

Development stage: Phase 3
Lead developer: MELISA Institute
Modality: Small Molecules
Administration: Oral

Overview

Previfenon is a pharmaceutical drug containing 250 mg of epigallocatechin-3-gallate (EGCG) with ≥ 98% purity, along with carefully selected excipients designed to improve flowability, stabilize EGCG against early auto-oxidation, and increase its hepatoprotective activity with prolonged use. Developed by MELISA Institute Genomics & Proteomics Research SpA, it is being investigated as a pre-exposure chemoprophylaxis against SARS-CoV-2 to prevent COVID-19, enhance systemic immunity, and reduce the frequency and intensity of associated symptoms.

Brand names: Previfenon

Targets

HMGB1 (High mobility group protein B1)ACE2 (Angiotensin-converting enzyme 2)SARS-CoV-2 spikeNF-κBMpro (3C-like proteinase of SARS-CoV-2)TMPRSS2 (Transmembrane protease serine 2)PLpro (Papain-like protease)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)HSPA5 (Heat shock protein family A member 5)

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