pridinol

Pridinol is a centrally acting muscle relaxant and anticholinergic agent of the piperidine class. It is primarily used for the symptomatic treatment of muscle spasms, muscle pain associated with tightness, and as an adjunct in managing conditions such as Parkinson's disease and other neuromuscular disorders. Its mechanism of action involves competitive antagonism at muscarinic acetylcholine receptors (mAChRs), thereby inhibiting acetylcholine-mediated neurotransmission in both central and peripheral nervous systems. This leads to reduced excitability of muscle fibers, alleviating involuntary movements, spasms, and stiffness. Pridinol also acts by reducing polysynaptic reflexes through its atropine-like effects on spinal motor neurons[1][4][5][8]. The drug is rapidly absorbed after oral administration, widely distributed including into the CNS, metabolized mainly by CYP2C19 and CYP2B6 enzymes in the liver to 4-hydroxypridinol, and excreted renally[8]. It has been approved for medical use in several countries since at least 2020[4].

Brand names

MyopridinNonplesinLyseenRelmusPrindol

Other names

pridinol mesilate