prilocaine + bupivacaine

Prilocaine + bupivacaine is a combination anesthetic regimen being evaluated by **Ain Shams University** for the management of **postoperative pain** in patients undergoing ambulatory knee arthroscopy. This protocol, often referred to as "hybrid anesthesia," utilizes intrathecal hyperbaric prilocaine to provide rapid-onset, short-duration spinal anesthesia suitable for day-case surgery, combined with a peripheral nerve block (adductor canal block) using bupivacaine to provide extended postoperative analgesia. Both agents are amino-amide local anesthetics that function by inhibiting voltage-gated sodium channels on the neuronal membrane, thereby preventing the initiation and conduction of nerve impulses. The primary goal of this combination is to minimize the prolonged motor block typically associated with spinal bupivacaine while maintaining effective long-term pain control.

Other names

Hybrid Anesthesia (Prilocaine and Bupivacaine)intrathecal prilocaine and adductor canal block with bupivacaine