primed tracer infusion (isotopically labelled glucose, amino acids, and lipids)

This intervention consists of a primed infusion of isotopically labelled metabolites, specifically glucose, amino acids, and lipids. It is used as a metabolic research tool in clinical studies to evaluate the kinetics and metabolic clearance rates of hormones like glucagon. In the context of the study conducted by University Hospital, Gentofte, these tracers allow for the quantification of endogenous production and disposal of nutrients in patients with end-stage renal disease (chronic kidney disease) and liver cirrhosis compared to healthy controls. The "primed" aspect refers to an initial loading dose designed to rapidly achieve a steady-state concentration of the isotope in the blood pool, which is then maintained by a constant infusion to allow for accurate measurement of metabolic flux.

Other names

primed tracer infusionisotopically labelled glucose, amino acids and lipids