pristinamycin

Pristinamycin is an antibiotic of the streptogramin class, primarily used to treat infections caused by Gram-positive bacteria such as staphylococci (including methicillin-resistant Staphylococcus aureus) and streptococci. It is a natural product derived from the bacterium Streptomyces pristinaespiralis and consists of two synergistic components—pristinamycin IA (a streptogramin B/depsipeptide) and pristinamycin IIA (a macrolide/streptogramin A)—produced in a 30:70 ratio. Both components bind to the bacterial 50S ribosomal subunit, inhibiting protein synthesis by blocking transpeptidation and elongation processes. While each component alone has moderate bacteriostatic activity, together they act synergistically to produce potent bactericidal effects. Pristinamycin is administered orally and is indicated for conditions such as community-acquired pneumonia, tonsillitis due to Group A Streptococcus, bone and joint infections (especially prosthetic joint infection), and mycoplasma genitalium infection when other antibiotics have failed[1][3][4][5][6][7].

Brand names

Pyostacine

Other names

pristinamycinepristinamycin IApristinamycin IIA